Dr. Jochen Buck is a Professor of Biochemistry at Weill Cornell Medicine, New York, NY, USA.
In 1999 in collaboration with Dr. Lonny Levin, Dr. Jochen Buck purified and cloned mammalian soluble adenylyl cyclase (sAC). Together, Dr. Buck and Dr. Levin developed the most widely used genetic, pharmacologic, and immunologic reagents for studying sAC, and demonstrated that sAC in sperm is essential for male fertility. Most recently, in concert with Dr. Clemens Steegborn, Dr. Peter T. Meinke and his team at TDI, their shared laboratories designed, developed, and leveraged potent and drug-like sAC inhibitors to establish the revolutionary paradigm of non-hormonal, on-demand contraception in males.
For his MD/PhD at the University of Tübingen (Germany), Dr. Buck studied the effect of interferon on cancer cells. In his postdoctoral work at Memorial Sloan-Kettering Cancer Center, he purified both an autocrine B cell factor and the kit ligand (also called stem cell factor). Dr. Buck additionally identified a novel family of retinol-derived signaling molecules, the retro-retinoids. In 1992 Dr. Buck established his own, independent laboratory in the Department of Pharmacology at Weil Cornell Medicine, where he soon began his long-term collaboration with Dr. Lonny Levin.
